Regulatory Haplotypes inARG1Are Associated with Altered Bronchodilator Response

Criteria for bronchodilator response.

Bronchodilator reversibility to albuterol predicts bronchodilator response to salmeterol.

We read with interest the recent study by Fish et al (August 2001)1 showing that adding salmeterol to inhaled corticosteroid achieved superior control as compared to adding montelukast. However it is likely that the results were biased toward the long-acting 2-agonist as patients were required as an inclusion criteria to have at least 12% increase in FEV1 in response to albuterol. It is therefo...

Musical Aptitude Is Associated with AVPR1A-Haplotypes

Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and even creativity in music. In order to understand the neurobiological basis of music in human evo...

Mapping common regulatory variants to human haplotypes.

Inter-individual variation in gene expression has proven to be in part governed by genetic determinants, which may be trans- or cis-acting. The underlying cause of cis-acting regulatory variation has been identified in only a handful of the hundreds of genes shown to display differential allelic expression. In this report, we describe a systematic effort to map common cis-acting variants in 64 ...

Bronchodilator response in patients with normal baseline spirometry.

BACKGROUND Spirometry before and after bronchodilator is performed to assess air flow-limitation reversibility. In patients with normal baseline spirometry the frequency of a positive bronchodilator response, as defined by American Thoracic Society/European Respiratory Society criteria, has not been described. METHODS We retrospectively analyzed adult patients tested in 2 academic pulmonary ...